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[3-36] in supraphysiological [24, 25], but not in physiological doses [25] reduces appetite and food intake. Longterm studies in humans are not available to date. A two weeks continous PYY infusion in colectomized rats did not affect food intake and body weight [26], and data obtained from other animal studies are controversially discussed [27]. The duration of the present study may have been too short to detect relevant differences in body weight. However, most studies linking physiological ghrelin and PYY responses to food intake investigated the effects of only one meal. A relatively small but well performed study over 16 weeks did not show an effect of macronutrient intake and energy intake on preprandial ghrelin [21]. It needs, however, to be emphasized that food diaries, and not weighed food intake were used to assess energy intake in the present study, and a more rigorous appetite experiment might detect smaller effects. In addition, adaptation processes and counter regulatory responses in other satiety hormones than total ghrelin, such as acylated ghrelin, glucagon-like peptide GLP-1 ; , or cholecystokinin may have masked detectable differences in energy intake or body weight and isoptin, for example, hypertension.
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David Williams, MD, of the Ohio State University Comprehensive Cancer Center's Pediatric Oncology Program, received the Donald Metcalf Award at the 35th meeting of the International Society of Experimental Hematology ISEH ; . The highest honor given by the ISEH, the Metcalf Award goes to scientists who have made significant contributions to experimental hematology. Williams, a professor of pediatrics and director of the Division of Experimental Hematology at Cincinnati Children's Hospital Medical Center, also presented the fifth annual Frank A. Oski Memorial Lecture at the 19th annual meeting of the American Society of Pediatric Hematology Oncology, held last spring in affiliation with the Pediatric Academic Societies and an alliance of pediatric subspecialty and research organizations. Williams' lecture topic was "Cell-Cell Interactions in the Bone Marrow: How Basic Studies in Stem Cell Biology Informed New Therapeutics in Cancer and Gene Therapy." Jian Wang, PhD, an assistant professor of Radiation Medicine at the OSU James Cancer Hospital and Solove Research Institute, has been appointed as a committee member of Radiation and Cancer Biology for ASTRO 2007, the 49th annual meeting of the American Society for Therapeutic Radiology and Oncology. ASTRO 2007 will be held Oct. 27-Nov. 1, 2007, in Los Angeles. The ASTRO Web site describes the annual meeting as the premier educational and scientific event for radiology oncology professionals. Wang also has been named a senior editor by Medjaden, a Hong Kong-based editing company that provides professional services for laboratory researchers, postgraduates and clinical physicians. The National Cancer Institute NCI ; and National Human Genome Research Institute NHGRI ; have selected the Gynecologic Oncology Group tissue bank at Children's Hospital in Columbus as the source for ovarian cancer biospecimens to be studied in the pilot phase of The Cancer Genome Atlas TCGA ; project. The tissue bank is under the supervision of Stephen Qualman, MD, professor of Pathology, principal investigator of the Biopathology Center at Children's Hospital, and co-leader of the Ohio State University Comprehensive Cancer Center's OSUCCC ; Pediatric Oncology Program. Qualman is also co-leader of the OSUCCC's Tissue Procurement Shared Resource. The NCI and NHGRI selected ovarian, lung and brain glioblastoma ; cancers to be studied in the pilot phase of TCGA, a collaborative three-year initiative that will test the feasibility of using large-scale genome analysis technologies to determine all of the important genomic changes involved in cancer. These three cancer types, which collectively account for more than 210, 000 cancer cases each year in the United States, were selected because of the availability of biospecimen collections that meet TCGA's strict scientific, technical and ethical requirements. The lung cancer biospecimens will be provided by the Lung Cancer Tissue Bank of the Cancer and Leukemia Group B CALGB ; clinical trials group housed at Brigham and Women's and doxazosin.
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ECHOCARDIOGRAPHIC EVALUATION OF DIASTOLIC FUNCTION IN NORMAL, MATURE SMALL BREED DOGS AND DOGS WITH ASYMPTOMATIC, SPONTANEOUS CHRONIC DEGENERATIVE VALVULAR DISEASE. A.B. Saunders, S.G. Gordon, M.W. Miller, Department of Small Animal Clinical Sciences and Michael E. DeBakey Institute, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX. Chronic degenerative valve disease CVD ; is the most common form of canine heart disease and the leading cause of heart failure in the dog. Valvular regurgitation resulting in myocardial stress and remodeling may lead to diastolic dysfunction. Echocardiography Echo ; is a noninvasive method of evaluating diastolic dysfunction in dogs. The purpose of this study was to collect and compare Doppler Echo measurements in normal NL ; , mature small breed dogs n 29 ; and dogs with various degrees of spontaneous CVD n 20 ; . All dogs were evaluated with a complete history, physical examination, Echo, ECG, Doppler blood pressure, thoracic radiographs, biochemistry panel, complete blood count and urinalysis. Blood work was used to document normovolemia and radiographs confirmed the absence of pulmonary edema. Measured Echo parameters included mitral inflow peak E and A wave and velocity time integral VTIE, VTIA ; , deceleration time of E wave DTE ; , ratio of E to wave E: A ; , as well as lateral mitral annular peak Ea, Aa, Sa velocities, and ratio of peak E to peak Ea E: Ea ; The Index of Myocardial Performance IMP ; , a global measurement of left ventricular systolic and diastolic performance, was calculated. Mean age in years CVD 8.9; NL 8.6 ; , weight in kg CVD 8.1; NL 9.3 ; and heart rate in bpm CVD 83; NL 95.1 ; were not significantly different between groups. CVD dogs varied in degree of severity as evidenced by the range in atrial size based on left atrial to aorta Mmode CVD 1.20, 0.8-1.7; NL 1.05, 0.7-1.5 ; and two dimensional CVD 1.59, 1.1-2.5; NL 1.29, 0.7-1.8 ; measurements and elevated vertebral heart scores CVD 11.3, 10-13; NL 10.0, 8.5-11.3 ; reported as mean and range. Differences were identified by Student's t test and results are recorded in the table as mean + - SE, * significant differences P 0.05 and mesylate.
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Immunol 2002; 89: 419-424. Ternesten-Hasseus E, Farbrot A, Lowhagen O, Millqvist E. Sensitivity to methacholine and capsaicin in patients with unclear respiratory symptoms. Allergy 2002; 57: 501-507. Pecova R, Frlickova Z, Pec J, Tatar M. Cough sensitivity in atopic dermatitis. Pulm Pharmacol Ther 2003; 16: 203-206.
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